Division of Cardiology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Division of Cardiology, Department of Medicine, Hartford Hospital, Hartford, CT, USA.
J Clin Lipidol. 2017 Sep-Oct;11(5):1134-1144. doi: 10.1016/j.jacl.2017.07.003. Epub 2017 Jul 21.
We sought to review studies examining the effect of statins on symptoms of exercise tolerance, markers of muscle injury and activity levels in physical active individuals.
Statin therapy reduces atherosclerotic cardiovascular disease (CVD) events. Regular physical activity is also associated with reduced CVD events, but statin therapy can produce muscle complaints, which may be more frequent in physically active individuals. We reviewed the literature to determine the effects of statins on symptoms, exercise performance and activity levels in physically active individuals.
We performed a PubMed search to identify English language articles reporting on statins and their effect on athletic/exercise performance, and symptoms in active individuals.
We identified 65 articles, 32 of which provided sufficient information to be included in this review. Seventeen of the 32 studies examined the incidence of myalgia while exercising on statins, and showed that myalgia was increased in 8 of the 17 (47%) of these studies. Of the 17 studies examining the effects of statin therapy on muscle injury, 6 (35%) studies reported that statins augment the increase in creatine kinase (CK) produced by exercise. There were 10 studies that examined statin effects on aerobic exercise performance, only 3 of which (33%) concluded that statins decreased performance. Two (25%) of the 8 studies examined the effects of statins on muscular strength and suggested that statins decreased muscular strength, whereas 2 (25%) reported increased strength. Statins did not consistently affect physical activity levels since statins were associated with an increase in activity in 3 of the 5 studies examining habitual exercise. None of the studies showed a relationship between statins use and exercise and an increase in myalgia or a decrease in exercise performance. There was also no correlation between intensity of statin therapy and an effect on these variables.
Statins may increase the incidence of exercise-related muscle complaints and in some studies augment the exercise-induced rise in muscle enzymes, but statins do not consistently reduce muscle strength, endurance, overall exercise performance or physical activity.
我们旨在回顾研究他汀类药物对运动耐量症状、肌肉损伤标志物和活跃人群活动水平的影响。
他汀类药物治疗可降低动脉粥样硬化性心血管疾病（CVD）事件。经常进行身体活动也与降低 CVD 事件相关，但他汀类药物可能会引起肌肉不适，在身体活跃的人群中可能更为常见。我们回顾了文献，以确定他汀类药物对身体活跃人群的症状、运动表现和活动水平的影响。
我们在 PubMed 上进行了搜索，以确定报告他汀类药物及其对活跃个体运动/运动表现和症状影响的英文文章。
我们共确定了 65 篇文章，其中 32 篇提供了足够的信息以纳入本综述。在这 32 项研究中，有 17 项研究检查了在服用他汀类药物时运动时肌痛的发生率，并表明在这 17 项研究中有 8 项（47%）的肌痛增加。在 17 项研究中，有 6 项（35%）研究报告他汀类药物增加了运动引起的肌酸激酶（CK）升高。有 10 项研究检查了他汀类药物对有氧运动表现的影响，其中只有 3 项（33%）的研究表明他汀类药物降低了运动表现。在 8 项研究中，有 2 项（25%）研究了他汀类药物对肌肉力量的影响，表明他汀类药物降低了肌肉力量，而 2 项（25%）报告了肌肉力量的增加。他汀类药物对活动水平的影响并不一致，因为在 5 项研究中有 3 项研究表明他汀类药物与习惯性运动的活动增加有关。没有一项研究表明他汀类药物的使用与运动之间存在关系，以及与肌痛增加或运动表现下降有关。他汀类药物治疗的强度与这些变量的影响之间也没有相关性。
他汀类药物可能会增加与运动相关的肌肉不适的发生率，并且在某些研究中会增加运动引起的肌肉酶升高，但他汀类药物并不一致地降低肌肉力量、耐力、整体运动表现或活动水平。
