中国北方人群中，与 HLA-B*2705 相比，HLA-B*2704 阳性的强直性脊柱炎患者更易发生葡萄膜炎。
Ankylosing Spondylitis Patients with HLA-B*2704 have More Uveitis than Patients with HLA-B*2705 in a North Chinese Population.
机构信息
a Third Affiliated Hospital of Sun Yat-sen University, General Hospital of Ningxia Medical University , Department of Rheumatology , Yinchuan , China.
b Third Affiliated Hospital of Sun Yat-sen University , Department of Rheumatology , Guangzhou , China.
出版信息
Ocul Immunol Inflamm. 2018;26(1):65-69. doi: 10.1080/09273948.2016.1188967. Epub 2016 Jul 18.
PURPOSE
To investigate the correlation between clinical features of ankylosing spondylitis (AS) and different human leukocyte antigen (HLA)-B27 subtypes.
METHODS
We conducted a cross-sectional study of 216 patients with AS. HLA-B27 and its subtypes were detected by polymerase chain reaction with sequence specific primer (PCR-SSP). Clinical features were compared between the different HLA-B27 subtypes. A meta-analysis on uveitis frequencies in AS patients with HLA-B*2705 vs 2704 was performed.
RESULTS
The most prevalent subtypes of HLA-B27 were HLA-B2704 (66.1%) and HLA-B2705 (32.2%). There were 57 HLA-B27-positive AS patients with the history of uveitis; 45 were B2704 and 12 were B2705. Patients with B2704 had more uveitis than B2705 (p = 0.021). After meta-analysis, there was no significant difference in the presence of uveitis between HLA-B2704 and HLA-B2705.
CONCLUSIONS
AS patients with B2704 have a higher risk of uveitis than AS with B2705 in a north Chinese people.
目的
探讨强直性脊柱炎（AS）的临床特征与不同人类白细胞抗原（HLA）-B27 亚型之间的相关性。
方法
我们对 216 例 AS 患者进行了横断面研究。采用聚合酶链反应序列特异性引物（PCR-SSP）检测 HLA-B27 及其亚型。比较不同 HLA-B27 亚型之间的临床特征。对 HLA-B*2705 与 2704 相比 AS 患者葡萄膜炎频率进行荟萃分析。
结果
HLA-B27 最常见的亚型是 HLA-B2704（66.1%）和 HLA-B2705（32.2%）。有 57 例 HLA-B27 阳性 AS 患者有葡萄膜炎病史；其中 45 例为 B2704，12 例为 B2705。B2704 患者的葡萄膜炎发生率高于 B2705（p=0.021）。荟萃分析后，HLA-B2704 和 HLA-B2705 之间葡萄膜炎的存在无显著差异。
结论
在中国北方人群中，与 HLA-B2705 相比，B2704 携带的 AS 患者发生葡萄膜炎的风险更高。
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