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采用传统前路钢板的颈椎前路减压融合术(ACDF)与人工颈椎间盘置换术后患者报告的吞咽困难发生率比较。

Comparison of the incidence of patient-reported post-operative dysphagia between ACDF with a traditional anterior plate and artificial cervical disc replacement.

作者信息

Yang Yi, Ma Litai, Liu Hao, Liu Yilian, Hong Ying, Wang Beiyu, Ding Chen, Deng Yuxiao, Song Yueming, Liu Limin

机构信息

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Department of Ecology and Evolutionary Biology, University of California, Los Angeles, USA.

出版信息

Clin Neurol Neurosurg. 2016 Sep;148:72-8. doi: 10.1016/j.clineuro.2016.07.020. Epub 2016 Jul 11.

Abstract

PURPOSE

Compared with anterior cervical discectomy and fusion (ACDF), cervical disc replacement (CDR) has provided satisfactory clinical results. The incidence of post-operative dysphagia between ACDF with a traditional anterior plate and CDR remains controversial. Considering the limited studies and knowledge in this area, a retrospective study focusing on post-operative dysphagia was conducted.

METHODS

The Bazaz grading system was used to assess the severity of dysphagia at post-operative intervals including 1 week, 1 month, 3 months, 6 months, 12 months and 24 months respectively. The Chi-square test, Student t-test, Mann-Whitney U tests and Ordinal Logistic regression were used for data analysis when appropriate. Statistical significance was accepted at a probability value of <0.05.

RESULTS

Two hundred and thirty-one patients in the CDR group and one hundred and fifty-eight patients in Plate group were included in this study. The total incidences of dysphagia in the CDR and plate group were 36.58% and 60.43% at one week, 29.27% and 38.85% at one month, 21.95% and 31.65% at three months, 6.83% and 17.99% at six months, 5.85% and 14.39% at 12 months, and 4.39% and 10.07% at the final follow-up respectively (All P<0.05, Mann-Whitney U test). Ordinal Logistic regression analysis showed that female patients, two-level surgery, C4/5 surgery, and anterior cervical plating were significant risk factors for post-operative dysphagia (all P<0.05).

CONCLUSION

Comparing ACDF with a plate, CDR with a Prestige LP can significantly reduce both transient and persistent post-operative dysphagia. Female patients, two-level surgery, C4/5 surgery and anterior cervical plating were associated with a higher incidence of dysphagia. Future prospective, randomized, controlled studies are needed to further validate these findings.

摘要

目的

与颈椎前路椎间盘切除融合术(ACDF)相比,颈椎间盘置换术(CDR)已取得了令人满意的临床效果。采用传统前路钢板的ACDF与CDR术后吞咽困难的发生率仍存在争议。鉴于该领域的研究和认识有限,开展了一项针对术后吞咽困难的回顾性研究。

方法

采用Bazaz分级系统分别评估术后1周、1个月、3个月、6个月、12个月和24个月时吞咽困难的严重程度。在适当的时候,使用卡方检验、学生t检验、曼-惠特尼U检验和有序逻辑回归进行数据分析。当概率值<0.05时接受统计学显著性。

结果

本研究纳入了CDR组的231例患者和钢板组的158例患者。CDR组和钢板组吞咽困难的总发生率在术后1周分别为36.58%和60.43%,1个月时分别为29.27%和38.85%,3个月时分别为21.95%和31.65%,6个月时分别为6.83%和17.99%,12个月时分别为5.85%和14.39%,末次随访时分别为4.39%和10.07%(所有P<0.05,曼-惠特尼U检验)。有序逻辑回归分析表明,女性患者、双节段手术、C4/5节段手术和颈椎前路钢板固定是术后吞咽困难的显著危险因素(所有P<0.05)。

结论

与使用钢板的ACDF相比,使用Prestige LP的CDR可显著降低术后短暂性和持续性吞咽困难的发生率。女性患者、双节段手术、C4/5节段手术和颈椎前路钢板固定与吞咽困难的较高发生率相关。未来需要进行前瞻性、随机、对照研究以进一步验证这些发现。

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