Carleo Alfonso, Bennett David, Rottoli Paola
aDepartment of Pulmonology, Hannover Medical School, Hannover, Germany bRespiratory Diseases and Lung Transplantation Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Curr Opin Pulm Med. 2016 Sep;22(5):509-14. doi: 10.1097/MCP.0000000000000306.
System biology is an interdisciplinary approach with the purpose to evaluate the experimental results of '-omics' sciences as a whole. The '-omics' sciences do not start generally from a-priori assumptions and are aimed to study the constituents of a specific biological domain (genome, transcriptome, proteome and metabolome) in a given state, using different high-throughput technologies (as polymerase chain reaction, arrays, liquid chromatography, mass spectrometry, etc.) and allowing a hermeneutical integration and recomposition of the experimental information. The aim of the present review is to explore the main new findings of system biology studies applied to sarcoidosis in the last year.
The main new findings of sarcoidosis that were highlighted by different studies in the last year (including miRNAs, TGF-β pathway, TNF-α and related proteins, vesicle trafficking, vitamin D and lipid metabolism, analyzed by system biology) are presented in this article.
System biology is a useful approach to combine different experimental results to study the pathogenesis of sarcoidosis and to identify groups of new molecules and mediators with potential clinical application as biomarkers.
系统生物学是一种跨学科方法，旨在整体评估“组学”科学的实验结果。“组学”科学通常并非从先验假设出发，而是利用不同的高通量技术（如聚合酶链反应、阵列、液相色谱、质谱等），研究特定生物领域（基因组、转录组、蛋白质组和代谢组）在给定状态下的组成部分，并对实验信息进行诠释性整合与重组。本综述的目的是探讨去年应用于结节病的系统生物学研究的主要新发现。
本文介绍了去年不同研究突出的结节病主要新发现（包括通过系统生物学分析的微小RNA、转化生长因子-β途径、肿瘤坏死因子-α及相关蛋白、囊泡运输、维生素D和脂质代谢）。
系统生物学是一种有用的方法，可将不同的实验结果结合起来，用于研究结节病的发病机制，并识别具有潜在临床应用价值作为生物标志物的新分子和介质组。
