Tran Duc N, Battilocchio Claudio, Lou Shing-Bong, Hawkins Joel M, Ley Steven V
Innovative Technology Centre , Department of Chemistry University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK . Email:
Pfizer Worldwide Research and Development , Eastern Point Road , Groton , CT 06340 , USA.
Chem Sci. 2015 Feb 1;6(2):1120-1125. doi: 10.1039/c4sc03072a. Epub 2014 Nov 7.
The work takes advantage of an important feature of flow chemistry, whereby the generation of a transient species (or reactive intermediate) can be followed by a transfer step into another chemical environment, before the intermediate is reacted with a coupling partner. This concept is successfully applied to achieve a room temperature sp-sp cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO as the oxidant.
这项工作利用了流动化学的一个重要特性，即瞬态物种（或反应中间体）生成后，在中间体与偶联伙伴反应之前，可以通过转移步骤进入另一种化学环境。这一概念已成功应用于实现硼酸与重氮化合物在室温下的sp-sp交叉偶联，后者是在流动条件下以MnO为氧化剂由腙生成的。
