Deadman Benjamin J, Collins Stuart G, Maguire Anita R
Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork (Ireland).
Chemistry. 2015 Feb 2;21(6):2298-308. doi: 10.1002/chem.201404348. Epub 2014 Nov 17.
The synthetic utilities of the diazo and diazonium groups are matched only by their reputation for explosive decomposition. Continuous processing technology offers new opportunities to make and use these versatile intermediates at a range of scales with improved safety over traditional batch processes. In this minireview, the state of the art in the continuous flow processing of reactive diazo and diazonium species is discussed.
重氮基和重氮鎓基团的合成效用仅与其爆炸性分解的名声相匹配。连续加工技术提供了新的机会，能够在一系列规模下制备和使用这些多功能中间体，且安全性优于传统间歇式工艺。在这篇微型综述中，讨论了活性重氮基和重氮鎓物种连续流动加工的现状。
