Choi Kwang-Eon, Yun Cheolmin, Kim Young-Ho, Kim Seong-Woo, Oh Jaeryung, Huh Kuhl
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Retina. 2017 Mar;37(3):568-577. doi: 10.1097/IAE.0000000000001170.
To evaluate the effect of photobleaching on fundus autofluorescence (FAF) images in acute central serous chorioretinopathy.
We obtained prephotobleaching and postphotobleaching images using an Optomap 200Tx, and photobleaching was induced with a Heidelberg Retina Angiograph 2. Degrees of photobleaching were assessed as grayscale values in Optomap images. Concordances among the three kinds of images were analyzed. Hyper-AF lesions in prephotobleaching images were classified as Type 1 (changed to normal-AF after photobleaching) and Type 2 (unchanged after photobleaching). The FAF composite patterns of central serous chorioretinopathy lesions were classified as diffuse or mottled. Initial and final best-corrected visual acuity, central retinal thickness, and disease duration were compared according to fovea FAF type.
Forty-one eyes of 41 patients were analyzed. The lesion brightness of postphotobleaching Optomap FAF showed greater concordance with Heidelberg Retina Angiograph 2 FAF (94.74%) than the prephotobleaching Optomap FAF (80.49%). Eyes with Type 1 fovea had greater initial and final best-corrected visual acuity (20/23 vs. 20/41, 20/21 vs. 20/32, P < 0.0001, P = 0.001, respectively) and shorter disease duration (19.68 ± 12.98 vs. 51.55 ± 44.98 days, P = 0.043) than those with Type 2 fovea. However, eyes with diffuse Type 2 fovea had only lower initial and final best-corrected visual acuity (20/23 vs. 20/45, 20/21 vs. 20/36, P < 0.0001, P < 0.0001, respectively) than those with Type 1 fovea.
Understanding the photobleaching effect is necessary for the accurate interpretation of FAF images. Furthermore, comparing prephotobleaching and postphotobleaching FAF images may be helpful for estimation of lesion status in central serous chorioretinopathy.
评估光漂白对急性中心性浆液性脉络膜视网膜病变眼底自发荧光（FAF）图像的影响。
我们使用Optomap 200Tx获取光漂白前和光漂白后的图像，并用海德堡视网膜血管造影仪2诱导光漂白。光漂白程度以Optomap图像中的灰度值评估。分析三种图像之间的一致性。将光漂白前图像中的高自发荧光病变分为1型（光漂白后变为正常自发荧光）和2型（光漂白后不变）。根据黄斑区自发荧光类型比较初始和最终最佳矫正视力、中心视网膜厚度及病程。
分析了41例患者的41只眼。光漂白后Optomap自发荧光的病变亮度与海德堡视网膜血管造影仪2自发荧光的一致性（94.74%）高于光漂白前Optomap自发荧光（80.49%）。1型黄斑区的眼睛初始和最终最佳矫正视力更高（分别为20/23 vs. 20/41，20/21 vs. 20/32，P < 0.0001，P = 0.001），病程更短（19.68 ± 12.98天 vs. 51.55 ± 44.98天，P = 0.043），而2型黄斑区的眼睛相比。然而，2型弥漫性黄斑区的眼睛初始和最终最佳矫正视力仅低于1型黄斑区的眼睛（分别为20/23 vs. 20/45，20/21 vs. 20/36，P < 0.0001，P < 0.0001）。
了解光漂白效应对于准确解读自发荧光图像是必要的。此外，比较光漂白前和光漂白后的自发荧光图像可能有助于评估中心性浆液性脉络膜视网膜病变的病变状态。
