Molecular Oncology and Viral Pathology Group, Research Centre (CI-IPOP), Porto, Portugal.
Faculty of Medicine of University of Porto (FMUP), Porto, Portugal.
J Med Virol. 2017 Mar;89(3):373-387. doi: 10.1002/jmv.24633. Epub 2016 Dec 5.
The Epstein-Barr Virus (EBV) is associated with the development of several diseases, including infectious mononucleosis (IM), Burkitt's Lymphoma (BL), Nasopharyngeal Carcinoma, and other neoplasias. The publication of EBV genome 1984 led to several studies regarding the identification of different viral strains. Currently, EBV is divided into EBV type 1 (B95-8 strain) and EBV type 2 (AG876 strain), also known as type A and type B, which have been distinguished based upon genetic differences in the Epstein-Barr nuclear antigens (EBNAs) sequence. Several other EBV strains have been described in the past 10 years considering variations on EBV genome, and many have attempted to clarify if these variations are ethnic or geographically correlated, or if they are disease related. Indeed, there is an increasing interest to describe possible specific disease associations, with emphasis on different malignancies. These studies aim to clarify if these variations are ethnic or geographically correlated, or if they are disease related, thus being important to characterize the epidemiologic genetic distribution of EBV strains on our population. Here, we review the current knowledge on the different EBV strains and variants and its association with different diseases. J. Med. Virol. 89:373-387, 2017. © 2016 Wiley Periodicals, Inc.
EB 病毒（EBV）与多种疾病的发生有关，包括传染性单核细胞增多症（IM）、伯基特淋巴瘤（BL）、鼻咽癌和其他肿瘤。1984 年 EBV 基因组的公布引发了多项关于鉴定不同病毒株的研究。目前，EBV 分为 EBV 类型 1（B95-8 株）和 EBV 类型 2（AG876 株），也称为 A 型和 B 型，它们是根据 EBV 核抗原（EBNAs）序列中的遗传差异来区分的。在过去的 10 年中，已经描述了其他几种 EBV 株，考虑到 EBV 基因组的变异，许多人试图澄清这些变异是与种族相关还是与地理位置相关，或者与疾病相关。事实上，人们越来越有兴趣描述可能存在的特定疾病相关性，重点是不同的恶性肿瘤。这些研究旨在澄清这些变异是与种族相关还是与地理位置相关，或者与疾病相关，因此，对描述 EBV 株在我们人群中的流行病学遗传分布具有重要意义。在这里，我们回顾了不同 EBV 株和变体的最新知识及其与不同疾病的关联。医学病毒学杂志 89:373-387, 2017。© 2016 年 Wiley 期刊，Inc.
