Pullar T, Dale S, Lowe J, Bird H
Department of Medicine, University of Leeds.
Br J Rheumatol. 1989 Aug;28(4):317-9. doi: 10.1093/rheumatology/28.4.317.
We have examined the effect of single dose indomethacin 50 mg on objective measurements of psychomotor function and whether this effect is altered by pretreatment with indomethacin 25 mg t.i.d. for 7 days in 10 healthy volunteers (5 male, 5 female; age 20-54 y). One hour after a single dose of indomethacin 50 mg there was significant impairment of psychomotor function (critical flicker fusion frequency threshold and choice reaction time) (Wilcoxon p less than 0.05). Pretreatment with indomethacin 25 mg t.i.d. for 7 days prevented this impairment. Thus we conclude that tolerance occurs over the course of a week to the psychomotor effects of indomethacin.
我们研究了50毫克单剂量吲哚美辛对精神运动功能客观测量指标的影响，以及在10名健康志愿者（5名男性，5名女性；年龄20 - 54岁）中，连续7天每日三次服用25毫克吲哚美辛预处理是否会改变这种影响。单次服用50毫克吲哚美辛1小时后，精神运动功能（临界闪烁融合频率阈值和选择反应时间）出现显著损害（Wilcoxon检验p值小于0.05）。连续7天每日三次服用25毫克吲哚美辛预处理可预防这种损害。因此我们得出结论，在一周的时间里会产生对吲哚美辛精神运动效应的耐受性。
