Pullar T, Myall O, Haigh J R, Lowe J R, Dixon J S, Bird H A
Department of Medicine, University of Leeds, UK.
Br J Rheumatol. 1988 Jun;27(3):227-9. doi: 10.1093/rheumatology/27.3.227.
We have compared the effect of single and multiple doses of indomethacin and placebo on objective measurements of psychomotor impairment in patients. Following a single 50 mg dose (n = 8), indomethacin produced psychomotor disturbance in only those patients who had no recent history of NSAID exposure. After multiple doses of indomethacin (25 and 50 mg tid for 5 days), significant psychomotor impairment was observed. We conclude that other NSAIDs may induce cross-tolerance to the psychomotor effects of indomethacin. Tachyphylaxis may develop to the psychomotor disturbance caused by indomethacin.
我们比较了单剂量和多剂量吲哚美辛及安慰剂对患者精神运动功能损害客观测量指标的影响。单次给予50mg剂量（n = 8）后，吲哚美辛仅在近期无非甾体抗炎药（NSAID）暴露史的患者中引起精神运动障碍。多次给予吲哚美辛（25mg和50mg，每日三次，共5天）后，观察到明显的精神运动功能损害。我们得出结论，其他NSAIDs可能会诱导对吲哚美辛精神运动效应的交叉耐受性。对吲哚美辛引起的精神运动障碍可能会产生快速耐受性。
