Hahn P, Seccombe D, Kirby L, Skala J
Experientia Suppl. 1978;32:61-7. doi: 10.1007/978-3-0348-5559-4_6.
Activity of phosphoenolpyruvate carboxykinase (PEPK) in brown adipose tissue (BAT) of infant rats is high and is depressed by a single injection of corti-costeroid or insulin. Both hormones inhibit synthesis of the enzyme in BAT and increase it in liver. Fatty acid synthetase activity is enhanced by these hormones, but only in BAT. It is suggested that corticosteroids may act via insulin release, since both blood glucose and blood insulin levels rise after steroid injection. The difference in response between BAT and liver is ascribed to the difference in adenyl cyclase response in the two tissues.
幼鼠棕色脂肪组织（BAT）中磷酸烯醇丙酮酸羧激酶（PEPK）的活性很高，单次注射皮质类固醇或胰岛素会使其活性降低。这两种激素均抑制BAT中该酶的合成，却使其在肝脏中的合成增加。这些激素可增强脂肪酸合成酶的活性，但仅在BAT中如此。有人提出，皮质类固醇可能通过胰岛素释放发挥作用，因为注射类固醇后血糖和血液胰岛素水平均会升高。BAT和肝脏反应的差异归因于这两种组织中腺苷酸环化酶反应的差异。
