Bright R A, Morrison A S, Brisson J, Burstein N A, Sadowsky N L, Kopans D B, Meyer J E
Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Cancer. 1989 Aug 1;64(3):653-7. doi: 10.1002/1097-0142(19890801)64:3<653::aid-cncr2820640315>3.0.co;2-o.
This study evaluates the effects of potential risk factors for benign breast disease (BBD) with special attention to the histologic and mammographic specificity of the effects. Cases were 172 women with BBD that underwent biopsy; controls were 134 women free of breast signs or symptoms. All cases and controls had undergone mammography. For all types of BBD combined, parity, use of oral contraceptives, and use of exogenous estrogen after menopause were strongly protective, whereas obesity and early menarche were weakly protective. Family history of breast cancer was virtually unrelated to BBD. The protective effect of parity was stronger for BBD with intralobular or extralobular fibrosis, and with mammographic homogeneous density or large nodular densities, than it was for BBD without these characteristics. Similar relations with the histologic and mammographic features were observed for obesity. These findings suggest that some risk factors for BBD have effects that are related to specific features of its morphology.
本研究评估了良性乳腺疾病（BBD）潜在风险因素的影响，并特别关注这些影响在组织学和乳腺X线摄影方面的特异性。病例为172例接受活检的BBD女性；对照为134例无乳腺体征或症状的女性。所有病例和对照均接受了乳腺X线摄影。对于所有类型的BBD综合来看，生育次数、口服避孕药的使用以及绝经后使用外源性雌激素具有很强的保护作用，而肥胖和初潮早则具有较弱的保护作用。乳腺癌家族史与BBD几乎无关。生育次数对伴有小叶内或小叶外纤维化、乳腺X线摄影表现为均匀密度或大结节状密度的BBD的保护作用，比对不具有这些特征的BBD更强。肥胖与组织学和乳腺X线摄影特征之间也观察到了类似的关系。这些发现表明，BBD的一些风险因素的影响与其形态学的特定特征有关。
