种群谱系对历史人口统计事件遗传特征的影响。
Effects of the population pedigree on genetic signatures of historical demographic events.
作者信息
Wakeley John, King Léandra, Wilton Peter R
机构信息
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
出版信息
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):7994-8001. doi: 10.1073/pnas.1601080113.
Genetic variation among loci in the genomes of diploid biparental organisms is the result of mutation and genetic transmission through the genealogy, or population pedigree, of the species. We explore the consequences of this for patterns of variation at unlinked loci for two kinds of demographic events: the occurrence of a very large family or a strong selective sweep that occurred in the recent past. The results indicate that only rather extreme versions of such events can be expected to structure population pedigrees in such a way that unlinked loci will show deviations from the standard predictions of population genetics, which average over population pedigrees. The results also suggest that large samples of individuals and loci increase the chance of picking up signatures of these events, and that very large families may have a unique signature in terms of sample distributions of mutant alleles.
二倍体双亲生物基因组中基因座间的遗传变异是突变以及通过物种的谱系或群体谱系进行遗传传递的结果。我们探讨了两种人口统计学事件对不连锁基因座变异模式的影响：近期出现的一个非常大的家族或一次强烈的选择性清除。结果表明，只有相当极端的此类事件才有望以这样一种方式构建群体谱系，即不连锁基因座会显示出偏离群体遗传学标准预测的情况，而群体遗传学标准预测是对群体谱系进行平均得到的。结果还表明，大量的个体和基因座样本增加了检测到这些事件特征的机会，而且就突变等位基因的样本分布而言，非常大的家族可能有独特的特征。
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