Sjaastad O, Saunte C, Salvesen R, Fredriksen T A, Seim A, Røe O D, Fostad K, Løbben O P, Zhao J M
Department of Neurology, Trondheim Hospital, Norway.
Cephalalgia. 1989 Jun;9(2):147-56. doi: 10.1046/j.1468-2982.1989.0902147.x.
Three grown-up males with a long-lasting history of rather uniform, unilateral headache in the ocular-periocular area, in cluster fashion, are examined. Pain paroxysms of short duration (15-60 sec) appear up to 5-30 times per h. The headache is unilateral without side shift. Conjunctival injection appears at the very beginning of the attack and is partly massive, lasting the entire duration of the attack, and fading away at the end of it. Tearing (massive), forehead sweating (subclinical) and rhinorrhea, all on the symptomatic side, accompany the attack. In the youngest patient, the headache became chronic after clustering for six months initially, and after approximately 3 1/2 years it became bilateral. However, even in this patient, a clear unilateral pain preponderance prevails, and the autonomic disturbances are all on the original pain side. Attacks can partly be precipitated by chewing, eating (e.g. citrus fruits), moving the head, etc. The headache is completely refractory to drug therapy, including indomethacin.
对三名成年男性进行了检查，他们长期患有眼部及眼周区域较为一致的单侧头痛，呈丛集性发作。短时间（15 - 60秒）的疼痛发作每小时出现5 - 30次。头痛为单侧性，无侧移。结膜充血在发作刚开始时出现，部分较为严重，持续整个发作过程，并在发作结束时消退。流泪（大量）、前额出汗（亚临床）和流涕，均出现在症状侧，伴随发作。最年轻的患者最初丛集发作六个月后头痛变为慢性，大约3年半后变为双侧性。然而，即使在该患者中，明显的单侧疼痛优势仍然存在，自主神经紊乱均出现在原来疼痛的一侧。发作部分可由咀嚼、进食（如柑橘类水果）、头部移动等诱发。头痛对包括吲哚美辛在内的药物治疗完全无效。
