a Department of Pharmacology, Faculty of Medicine , Babol University of Medical Sciences , Babol , Iran.
b Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , Tehran , Iran.
Expert Opin Drug Metab Toxicol. 2017 May;13(5):545-554. doi: 10.1080/17425255.2016.1214712. Epub 2016 Jul 29.
Pesticides are among the most important chemicals used in agriculture sector. However, their extensive use has polluted the environment and increased human vulnerability to various chronic diseases. Pesticide exposure causes genetic and epigenetic modifications, endocrine disruption, mitochondrial dysfunction and oxidative stress. Areas covered: This review is based on the literature studies currently reported on pesticide-induced toxicity and the protective role of melatonin. Scientific databases such as PubMed, Scopus and Web of Science were searched using keywords 'pesticide' and 'melatonin' up to January 2016. Full length articles related to animal and human exposure were retrieved. A total number of 181 records were obtained, and after excluding the duplicates, 97 papers were further screened on the basis of relevance to the topic. Expert opinion: Melatonin as a broad-spectrum antioxidant is able to penetrate cellular compartments specifically the mitochondria. It is a potent free radical scavenger with low toxicity and desirable solubility in organic and aqueous phases. We are of the opinion that melatonin is a promising agent in minimizing organ injuries induced by pesticides.
农药是农业领域中使用最广泛的化学物质之一。然而，它们的广泛使用已经污染了环境，增加了人类患各种慢性疾病的脆弱性。农药暴露会导致遗传和表观遗传修饰、内分泌干扰、线粒体功能障碍和氧化应激。涵盖领域：本综述基于目前关于农药诱导毒性和褪黑素保护作用的文献研究。使用关键词“pesticide”和“melatonin”在 PubMed、Scopus 和 Web of Science 等科学数据库中进行搜索，检索时间截至 2016 年 1 月。检索到与动物和人类暴露相关的全文文章。共获得 181 条记录，排除重复后，根据与主题的相关性进一步筛选了 97 篇论文。专家意见：褪黑素作为一种广谱抗氧化剂，能够穿透细胞区室，特别是线粒体。它是一种有效的自由基清除剂，毒性低，在有机相和水相中有良好的溶解性。我们认为，褪黑素是一种有前途的药物，可最大限度地减少农药引起的器官损伤。
