Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China.
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
BMC Womens Health. 2022 Mar 21;22(1):79. doi: 10.1186/s12905-022-01661-w.
Polycystic ovary syndrome (PCOS) is a common gynecologic disorder related to abnormal circadian rhythm. Therefore, we aimed to find whether the level of melatonin, a rhythm regulating hormone changed in the ovarian microenvironment in this disease.
The melatonin concentrations in follicular fluid (FF) were measured in 35 PCOS and 36 non-PCOS women undergoing in vitro fertilization (IVF) treatment.
The FF melatonin concentration was significantly lower in PCOS women than non-PCOS women (p = 0.045) and it was found positively correlated with serum basal FSH level (r = 0.308, p = 0.013). In IVF procedures, there was no significant difference in the fertilization rate of oocytes between the two groups, but the high-quality embryogenesis rate on the third day of the PCOS group was significantly lower than that of the control group (p = 0.042), which showed a weak positive correlation with the FF melatonin concentration (r = 0.240, p = 0.044). Furthermore, there was no significant difference in overall pregnancy outcome. The PSQI questionnaire showed that sleep disorders were more likely to exist in the PCOS group, though there was no significant difference.
The obtained results suggested PCOS women had lower melatonin concentrations in the ovarian microenvironment.
多囊卵巢综合征（PCOS）是一种常见的妇科疾病，与异常的昼夜节律有关。因此，我们旨在探讨卵巢微环境中调节节律的激素褪黑素水平是否在这种疾病中发生改变。
我们对 35 名 PCOS 患者和 36 名非 PCOS 患者的卵泡液（FF）中的褪黑素浓度进行了测量，这些患者均正在接受体外受精（IVF）治疗。
与非 PCOS 患者相比，PCOS 患者的 FF 褪黑素浓度显著降低（p=0.045），并且与血清基础 FSH 水平呈正相关（r=0.308，p=0.013）。在 IVF 过程中，两组卵母细胞的受精率无显著差异，但 PCOS 组第 3 天的优质胚胎形成率显著低于对照组（p=0.042），与 FF 褪黑素浓度呈弱正相关（r=0.240，p=0.044）。此外，两组的总体妊娠结局无显著差异。PSQI 问卷显示，PCOS 组更易出现睡眠障碍，但无统计学差异。
研究结果表明 PCOS 患者卵巢微环境中的褪黑素浓度较低。
