De Felice Antonia, Di Lorenzo Flaviana, Scherlach Kirstin, Ross Claudia, Silipo Alba, Hertweck Christian, Molinaro Antonio
Department of Chemical Sciences, University of Naples Federico II, via Cinthia 4, 80126, Naples, Italy.
Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany; Friedrich Schiller University, Jena, Germany.
Carbohydr Res. 2016 Oct 4;433:31-5. doi: 10.1016/j.carres.2016.07.008. Epub 2016 Jul 9.
Gram-negative bacteria exhibit lipopolysaccharides (LPSs) on their outer membrane surface. LPS is considered one of the most potent bacterial virulence factors. Here we report the elucidation of the LPS O-chain structure isolated from Burkholderia fungorum, a bacterium isolated from the white-rot fungus Phanerochaete chrysosporium that can act as a pathogen for plants and domesticated animals. The structure was determined by the employment of detailed chemical and NMR spectroscopy analyses as the following.
革兰氏阴性菌在其外膜表面呈现脂多糖（LPSs）。LPS被认为是最有效的细菌毒力因子之一。在此，我们报告了从伯克霍尔德氏菌中分离出的LPS O链结构的解析，该细菌是从白腐真菌黄孢原毛平革菌中分离得到的，它可作为植物和家畜的病原体。该结构通过详细的化学和核磁共振光谱分析确定如下。
