固相肽合成中由组氨酸和乙酸酐引起的意外链终止副反应。
Unexpected chain-terminating side reaction caused by histidine and acetic anhydride in solid-phase peptide synthesis.
作者信息
Ishiguro T, Eguchi C
出版信息
Chem Pharm Bull (Tokyo). 1989 Feb;37(2):506-8. doi: 10.1248/cpb.37.506.
PMID:2743502
Abstract
Capping is a useful technique to facilitate purification of a crude deprotected peptide in solid-phase peptide synthesis. However, we observed a serious side reaction caused by the Ac2O capping procedure, when it was applied to a synthesis of a peptide containing His. The mechanism of the side reaction was studied.
摘要
封端是一种有助于在固相肽合成中纯化粗脱保护肽的有用技术。然而，当将乙酸酐封端程序应用于含组氨酸肽的合成时，我们观察到了由该程序引起的严重副反应。对该副反应的机制进行了研究。
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