Mula Marco
Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, Department of Neuropsychiatry, South West London & St George's Mental Health Trust, London, Institute of Medical and Biomedical Sciences, St George's University of London, London, United Kingdom.
Epileptic Disord. 2016 Sep 1;18(3):217-27. doi: 10.1684/epd.2016.0837.
Anxiety disorders represent a common psychiatric comorbidity in patients with epilepsy, affecting prognosis and quality of life. However, they are still underdiagnosed and undertreated. In clinical practice, a number of compounds are currently used as anxiolytics, with benzodiazepines being the most popular. Other drug classes, especially antiepileptic drugs, are increasingly prescribed for the treatment of anxiety. This article discusses the neurobiological targets and basic neuropharmacological aspects of anxiolytics in order to give the reader clear insight into their activity and mechanism of action. Clinical data regarding the treatment of anxiety in both adults and children with epilepsy are also summarised, emphasising the need for further studies.
焦虑症是癫痫患者常见的精神共病，会影响预后和生活质量。然而，它们仍然存在诊断不足和治疗不足的问题。在临床实践中，目前有多种化合物被用作抗焦虑药，其中苯二氮䓬类最为常用。其他药物类别，尤其是抗癫痫药物，越来越多地被用于治疗焦虑症。本文讨论了抗焦虑药的神经生物学靶点和基本神经药理学方面，以便让读者清楚地了解它们的活性和作用机制。还总结了关于癫痫成人和儿童焦虑症治疗的临床数据，强调了进一步研究的必要性。
