Mendlewicz J, Sevy S
Encephale. 1985 Nov-Dec;11(6):255-9.
The widespread use of benzodiazepines has led the authors to review the pharmacological and clinical aspects of these substances. On a molecular level, the benzodiazepines have an effect on receptors in relation with the GABA system. Presently, endogenous ligand(s) to these receptors have not yet been fully demonstrated. The main benzodiazepines are also compared for their kinetics which is function of absorption, metabolisation and various factors such as binding to the receptor, age, hepatic and renal disorders. These pharmacological studies have clinical implications. The authors finally make a brief review of the clinical indications of the benzodiazepines.
苯二氮䓬类药物的广泛使用促使作者对这些物质的药理学和临床方面进行综述。在分子水平上，苯二氮䓬类药物对与γ-氨基丁酸（GABA）系统相关的受体有作用。目前，这些受体的内源性配体尚未得到充分证实。还比较了主要苯二氮䓬类药物的动力学，其是吸收、代谢以及诸如与受体结合、年龄、肝脏和肾脏疾病等各种因素的函数。这些药理学研究具有临床意义。作者最后简要综述了苯二氮䓬类药物的临床适应证。
