Sárközi Kitti, Papp András, Horváth Edina, Máté Zsuzsanna, Hermesz Edit, Kozma Gábor, Zomborszki Zoltán Péter, Kálomista Ildikó, Galbács Gábor, Szabó Andrea
Department of Public Health, University of Szeged Faculty of Medicine, Szeged, Hungary.
Department of Biochemistry and Molecular Biology, University of Szeged Faculty of Science and Informatics, Szeged, Hungary.
J Sci Food Agric. 2017 Apr;97(6):1717-1724. doi: 10.1002/jsfa.7919. Epub 2016 Aug 24.
Inhalation of manganese-containing metal fumes at workplaces can cause central nervous damage including a Parkinson-like syndrome. Oxidative stress is likely to be involved in the pathomechanism, due to the presence of nano-sized metal oxide particles with high biological and chemical activity. Oxidative damage of the nervous system could be prevented or ameliorated by properly applied antioxidants, preferably natural ones such as green tea, a popular drink. The aim of this work was to see if orally applied green tea brew could diminish the functional neurotoxicity of manganese dioxide nanoparticles introduced into the airways of rats.
Young adult male Wistar rats were treated intratracheally for 6 weeks with a suspension of synthetic MnO nanoparticles (4 mg/kg body weight), and received green tea brew (1 g leaves 200 mL water) as drinking fluid. Reduced body weight gain, indicating general toxicity of the nanoparticles, was not influenced by green tea. However, in rats receiving green tea the nervous system effects - changes in the spontaneous and evoked cortical activity and peripheral nerve action potential - were diminished.
The use of green tea as a neuroprotective functional drink seems to be a viable approach. © 2016 Society of Chemical Industry.
在工作场所吸入含锰金属烟雾可导致中枢神经损伤，包括帕金森样综合征。由于存在具有高生物和化学活性的纳米级金属氧化物颗粒，氧化应激可能参与其发病机制。通过适当应用抗氧化剂，最好是天然抗氧化剂，如广受欢迎的饮品绿茶，可预防或减轻神经系统的氧化损伤。这项研究的目的是观察口服绿茶冲泡液是否能减轻引入大鼠气道的二氧化锰纳米颗粒的功能性神经毒性。
成年雄性Wistar大鼠经气管内给予合成MnO纳米颗粒悬浮液（4毫克/千克体重），持续6周，并饮用绿茶冲泡液（1克茶叶兑200毫升水）。纳米颗粒的一般毒性表现为体重增加减少，这不受绿茶影响。然而，饮用绿茶的大鼠的神经系统效应——自发和诱发的皮层活动以及外周神经动作电位的变化——有所减轻。
将绿茶用作神经保护功能性饮品似乎是一种可行的方法。© 2016化学工业协会。
