Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Neuropharmacol. 2021;19(3):349-359. doi: 10.2174/1570159X18666200529152625.
Neurological disorders and their sequelae, as of the widespread and critical humans' complications, affect the body's nervous systems, organ functions, and behaviors. According to WHO, neurological disorders are currently predicted to affect more than one billion people globally. It is well-established that complementary medicine is one of the high accepted interventions that could have been considered for the management of neurological ailments. The current review aimed to compile all the crucial data reporting the investigation on the conspicuous intervention of green tea (made of Camellia sinensis) and related lead compounds (especially l-theanine, epigallocatechin- 3-gallate, epicatechin-3-gallate, epicatechin, and epigallocatechin) for their neurological activities, mechanisms of action, and clinical properties. According to the documents, green tea exhibits antidepressant, anti-neurodegenerative (e.g., anti-Parkinson and anti-Alzheimer), as well as neuroprotective effects.Chief among them, for offering novel work, it is worth focusing on several related assessments with great attention to more extensive standardized clinical trials, and subsequently more in-depth pharmacokinetic studies to safely introduce this beneficial medicinal food as a neuro-effective agent.
神经系统疾病及其后遗症是广泛而严重的人类并发症，会影响身体的神经系统、器官功能和行为。据世界卫生组织（WHO）预测，目前神经系统疾病在全球影响超过 10 亿人。补充医学是一种被广泛接受的干预措施，可用于治疗神经系统疾病。本综述旨在汇总所有关于绿茶（由茶树制成）及其相关先导化合物（特别是茶氨酸、表没食子儿茶素没食子酸酯、表儿茶素没食子酸酯、表儿茶素和表没食子儿茶素没食子酸酯）在神经活性、作用机制和临床特性方面的研究的关键数据。根据这些文献，绿茶具有抗抑郁、抗神经退行性（如抗帕金森病和抗阿尔茨海默病）和神经保护作用。其中，值得关注的是一些相关的评估，需要特别注意更广泛的标准化临床试验，以及随后更深入的药代动力学研究，以安全地将这种有益的药食同源作为神经有效药物引入。
