Rubila Sundararaj, Ranganathan Thottiam Vasudevan, Sakthivel Kunnathur Murugesan
Department of Food Processing and Engineering, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India.
Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India.
Appl Biochem Biotechnol. 2016 Dec;180(8):1482-1496. doi: 10.1007/s12010-016-2181-x. Epub 2016 Jul 19.
The aim of the present investigation was to evaluate Zingiber officinale paste against Dalton's lymphoma ascites (DLA)-induced tumours in Swiss albino mice. Experimental animals received Z. officinale paste (low dose 100 mg/kg bw and high dose 500 mg/kg bw) orally for eight alternative days. Treatment with Z. officinale paste showed significant increase in haemoglobin level and decrease in aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (γ-GT) level. Z. officinale paste reduced the inflammatory mediators and cytokine levels, such as inducible nitric oxide (iNOS), tumour necrosis factor level (TNF-α) and interleukin-1β (IL-1β). Treatment with Z. officinale paste also significantly increased the antioxidant enzyme level, such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione transferase (GST), and decreased the lipid peroxidation. Treatment also increased the vitamin C and E levels in treated animals compared with the DLA-bearing host. Histopathological studies also confirmed the protective influence of Z. officinale paste against DLA. The present study suggested that Z. officinale paste could be used as natural spice and a potent antitumour agent.
本研究的目的是评估生姜膏对瑞士白化小鼠中由道尔顿淋巴瘤腹水（DLA）诱导的肿瘤的作用。实验动物每隔一天口服低剂量100毫克/千克体重和高剂量500毫克/千克体重的生姜膏，持续八天。生姜膏治疗使血红蛋白水平显著升高，天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、碱性磷酸酶（ALP）和γ-谷氨酰转移酶（γ-GT）水平降低。生姜膏降低了炎症介质和细胞因子水平，如诱导型一氧化氮合酶（iNOS）、肿瘤坏死因子水平（TNF-α）和白细胞介素-1β（IL-1β）。生姜膏治疗还显著提高了抗氧化酶水平，如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、还原型谷胱甘肽（GSH）和谷胱甘肽转移酶（GST），并降低了脂质过氧化。与携带DLA的宿主相比，治疗还提高了治疗动物体内的维生素C和E水平。组织病理学研究也证实了生姜膏对DLA的保护作用。本研究表明，生姜膏可作为天然香料和一种有效的抗肿瘤剂。
