Szökő Éva, Vincze István, Tábi Tamás
Department of Pharmacodynamics, Semmelweis University, Nagyvárad tér 4. Budapest, H-1089, Hungary.
Department of Pharmacodynamics, Semmelweis University, Nagyvárad tér 4. Budapest, H-1089, Hungary.
J Pharm Biomed Anal. 2016 Oct 25;130:100-109. doi: 10.1016/j.jpba.2016.06.054. Epub 2016 Jul 1.
It is widely accepted that some of the free d-amino acids play important biological role. d-Aspartate and d-serine formed in the central nervous system of higher vertebrates have neurotransmitter/neuromodulator function. Together with d-alanine they are distributed in various tissues and biological fluids. Studying their physiological and pathological significance requires their sensitive and accurate determination in biological samples. The various separation and detection methods used for their analysis are overviewed in the present paper. Our focus is mainly the quantitative performance and the analysis of real biospecimens.
人们普遍认为，一些游离的d-氨基酸发挥着重要的生物学作用。在高等脊椎动物中枢神经系统中形成的d-天冬氨酸和d-丝氨酸具有神经递质/神经调质功能。它们与d-丙氨酸一起分布于各种组织和生物体液中。研究它们的生理和病理意义需要在生物样品中对其进行灵敏而准确的测定。本文综述了用于分析它们的各种分离和检测方法。我们主要关注的是定量性能以及实际生物样本的分析。
