Peçanha Tiago, de Brito Leandro Campos, Fecchio Rafael Yokoyama, de Sousa Patricia Nascimento, da Silva Junior Natan Daniel, de Abreu Andrea Pio, da Silva Giovanio Vieira, Mion-Junior Décio, Forjaz Cláudia Lúcia de Moraes
Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil.
Hypertension Unit, General Hospital, University of São Paulo, São Paulo, São Paulo, Brazil.
J Physiol. 2016 Nov 1;594(21):6211-6223. doi: 10.1113/JP272851. Epub 2016 Sep 21.
Recent evidence indicates that metaboreflex regulates heart rate recovery after exercise (HRR). An increased metaboreflex activity during the post-exercise period might help to explain the reduced HRR observed in hypertensive subjects. Using lower limb circulatory occlusion, the present study showed that metaboreflex activation during the post-exercise period delayed HRR in never-treated hypertensive men compared to normotensives. These findings may be relevant for understanding the physiological mechanisms associated with autonomic dysfunction in hypertensive men.
Muscle metaboreflex influences heart rate (HR) regulation after aerobic exercise. Therefore, increased metaboreflex sensitivity may help to explain the delayed HR recovery (HRR) reported in hypertension. The present study assessed and compared the effect of metaboreflex activation after exercise on HRR, cardiac baroreflex sensitivity (cBRS) and heart rate variability (HRV) in normotensive (NT) and hypertensive (HT) men. Twenty-three never-treated HT and 25 NT men randomly underwent two-cycle ergometer exercise sessions (30 min, 70% V̇O2 peak ) followed by 5 min of inactive recovery performed with (occlusion) or without (control) leg circulatory occlusion (bilateral thigh cuffs inflated to a suprasystolic pressure). HRR was assessed via HR reduction after 30, 60 and 300 s of recovery (HRR30s, HRR60s and HRR300s), as well as by the analysis of short- and long-term time constants of HRR. cBRS was assessed by sequence technique and HRV by the root mean square residual and the root mean square of successive differences between adjacent RR intervals on subsequent 30 s segments. Data were analysed using two- and three-way ANOVA. HRR60s and cBRS were significant and similarly reduced in both groups in the occlusion compared to the control session (combined values: 20 ± 10 vs. 26 ± 9 beats min and 2.1 ± 1.2 vs. 3.2 ± 2.4 ms mmHg , respectively, P < 0.05). HRR300s and HRV were also reduced in the occlusion session, although these reductions were significantly greater in HT compared to NT (-16 ± 11 vs. -8 ± 15 beats min for HRR300s, P < 0.05). The results support the role of metaboreflex in HRR and suggest that increased metaboreflex sensitivity may partially explain the delayed HRR observed in HT men.
近期证据表明，代谢反射调节运动后心率恢复（HRR）。运动后阶段代谢反射活动增加可能有助于解释高血压患者中观察到的HRR降低。本研究通过下肢循环闭塞发现，与血压正常者相比，未经治疗的高血压男性在运动后阶段的代谢反射激活会延迟HRR。这些发现可能有助于理解高血压男性自主神经功能障碍相关的生理机制。
肌肉代谢反射影响有氧运动后的心率（HR）调节。因此，代谢反射敏感性增加可能有助于解释高血压患者中报道的心率恢复延迟（HRR）。本研究评估并比较了运动后代谢反射激活对血压正常（NT）和高血压（HT）男性的HRR、心脏压力反射敏感性（cBRS）和心率变异性（HRV）的影响。23名未经治疗的HT男性和25名NT男性随机进行两周期的测力计运动（30分钟，70%最大摄氧量），随后进行5分钟的静息恢复，恢复过程中采用（闭塞）或不采用（对照）腿部循环闭塞（双侧大腿袖带充气至收缩压以上）。通过恢复30、60和300秒后的HR降低（HRR30s、HRR60s和HRR300s）以及HRR的短期和长期时间常数分析来评估HRR。通过序列技术评估cBRS，通过后续30秒段相邻RR间期之间的均方根残差和连续差值的均方根评估HRV。数据采用双因素和三因素方差分析。与对照试验相比，两组在闭塞试验中的HRR60s和cBRS均显著且类似地降低（合并值分别为：20±10次/分钟对26±9次/分钟和2.1±1.2毫秒/毫米汞柱对3.2±:2.4毫秒/毫米汞柱，P<0.05）。闭塞试验中HRR300s和HRV也降低，尽管HT组的这些降低比NT组显著更大（HRR300s为-16±11次/分钟对-8±15次/分钟，P<0.05）。结果支持代谢反射在HRR中的作用，并表明代谢反射敏感性增加可能部分解释了HT男性中观察到的HRR延迟。
