van den Meiracker A H, Man in 't Veld A J, Boomsma F, Schalekamp M A
Dept. of Internal Medicine I, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Clin Exp Hypertens A. 1989;11 Suppl 1:345-51. doi: 10.3109/10641968909045440.
The metabolism of norepinephrine (NE) and epinephrine (EPI) in peripheral tissues limits the use of venous plasma levels of these parameters as an index of overall sympathetic or adrenomedullary activity. Therefore venous (deep antecubital vein) and arterial (brachial artery) concentrations of NE and EPI were compared in 16 hypertensive subjects. NE and EPI were determined after 30 min supine rest, and immediately before and after isometric exercise, cold provocation, head-up tilting (OST) and Stroop's colour word test (CWT). At rest venous NE exceeds arterial NE. Assuming similar fractional extractions (FE) of NE and EPI, 46 +/- 14% (mean +/- SD) of venous NE appeared to be produced locally. Despite this considerable local production venous and arterial levels of NE were closely correlated (r = 0.92). At rest venous EPI was 42 +/- 13% lower than arterial EPI, but since the interindividual variation of the FE of EPI was relatively small and independent of arterial levels, venous and arterial levels were also closely correlated (r = 0.82). All four tests caused an increase in arterial and venous NE, whereas EPI did not change. Responses of arterial and venous NE were only correlated after OST and CWT. It is concluded that at rest, but not invariably so during different forms of sympatho-adrenal activation, arterial plasma concentrations of NE and EPI can be substituted for by their respective venous equivalents.
去甲肾上腺素（NE）和肾上腺素（EPI）在周围组织中的代谢限制了将这些参数的静脉血浆水平用作整体交感神经或肾上腺髓质活动指标的用途。因此，对16名高血压患者的静脉（肘前深静脉）和动脉（肱动脉）中NE和EPI的浓度进行了比较。在仰卧休息30分钟后、等长运动前、冷刺激前、头高位倾斜（OST）前和Stroop色词测试（CWT）前及后，测定NE和EPI。静息时静脉NE超过动脉NE。假设NE和EPI的分数提取率（FE）相似，静脉NE的46±14%（平均值±标准差）似乎是局部产生的。尽管局部产生量可观，但静脉和动脉中的NE水平密切相关（r = 0.92）。静息时静脉EPI比动脉EPI低42±13%，但由于EPI的FE个体间差异相对较小且与动脉水平无关，静脉和动脉水平也密切相关（r = 0.82）。所有四项测试均导致动脉和静脉NE升高，而EPI未改变。仅在OST和CWT后，动脉和静脉NE的反应才相关。结论是，静息时，而非在不同形式的交感-肾上腺激活过程中始终如此，动脉血浆中NE和EPI的浓度可用各自的静脉等效物替代。
