Halter J B, Pflug A E, Tolas A G
Metabolism. 1980 Jan;29(1):9-12. doi: 10.1016/0026-0495(80)90090-6.
To investigate the relationship between forearm venous levels of catecholamines and systemic levels, simultaneous arterial and forearm vein blood samples were obtained from 14 subjects undergoing elective dental procedures and assayed with a sensitive and specific radioenzymatic assay. Baseline venous levels of norepinephrine were greater than arterial levels (305 +/- 30 pg/ml versus 221 +/- 18; +/- SEM, p less than .005). Conversely, arterial epinephrine levels were higher than venous (132 +/- 17 pg/ml versus 80 +/- 10; p less than .005). There was a significant relationship between arterial and venous levels of both norepinephrine (r = .77, p less than .01) and epinephrine (r = .67, p less than .01). The arterial-venous epinephrine difference increased from the baseline value of 44 +/- 14 pg/ml to 108 +/- 16 (p less than .005) by 3 min after subcutaneous injection of epinephrine (18 microgram), but the arterial-venous difference returned to 65 +/- 24 by 5 min after injection (p = NS versus baseline). These findings indicate that under the conditions of this study, forearm tissues produced more norepinephrine than they removed, but removed more epinephrine than they produced. Baseline venous and arterial levels were related; when epinephrine production was augmented, there was a short time lag for the venous epinephrine increase.
为了研究前臂静脉中儿茶酚胺水平与全身水平之间的关系，我们从14名接受择期牙科手术的受试者身上同时采集了动脉血和前臂静脉血样本，并采用灵敏且特异的放射酶分析法进行检测。去甲肾上腺素的基线静脉水平高于动脉水平（305±30 pg/ml对221±18；±SEM，p<0.005）。相反，动脉肾上腺素水平高于静脉水平（132±17 pg/ml对80±10；p<0.005）。去甲肾上腺素和肾上腺素的动脉水平与静脉水平之间均存在显著相关性（去甲肾上腺素r = 0.77，p<0.01；肾上腺素r = 0.67，p<0.01）。皮下注射肾上腺素（18微克）后3分钟，动脉-静脉肾上腺素差值从基线值44±14 pg/ml增加到108±16（p<0.005），但注射后5分钟动脉-静脉差值恢复到65±24（与基线相比p = 无显著性差异）。这些发现表明，在本研究条件下，前臂组织产生的去甲肾上腺素多于其清除量，但清除的肾上腺素多于其产生量。基线静脉和动脉水平相关；当肾上腺素生成增加时，静脉肾上腺素增加存在短暂的时间滞后。
