Jo Y, Arita M, Baba A, Nakamura H, Ueda E, Hano T, Ueno Y, Kuchii M, Nishio I, Masuyama Y
Department of Medicine, Wakayama Medical College, Japan.
Clin Exp Hypertens A. 1989;11 Suppl 1:411-7. doi: 10.3109/10641968909045448.
Fourteen untreated patients with essential hypertension (EH) were subjected to mild aerobic exercise with the intensity at 50% of the maximum oxygen uptake (VO2max) twice a week for 12 weeks, as compared with 14 normotensive subjects (NT). Blood pressure and norepinephrine (NE) in plasma, platelet and urine were measured as the indices of sympathetic activity. In EH, a significant fall in both systolic and diastolic blood pressure was observed. In addition, exercise training produced a significant decrease both urinary and platelet NE, but not in plasma NE. Neither significant changes in blood pressure nor NE in plasma, platelet and urine were observed in NT. These results suggest that an inhibition of the sympathetic nervous system might be related to the blood pressure fall in physical exercise training.
14例未经治疗的原发性高血压（EH）患者进行轻度有氧运动，运动强度为最大摄氧量（VO2max）的50%，每周两次，共12周，与14例血压正常的受试者（NT）进行比较。测量血浆、血小板和尿液中的血压和去甲肾上腺素（NE）作为交感神经活动指标。在EH患者中，观察到收缩压和舒张压均显著下降。此外，运动训练使尿液和血小板中的NE显著降低，但血浆NE未降低。在NT患者中，血浆、血小板和尿液中的血压和NE均未观察到显著变化。这些结果表明，交感神经系统的抑制可能与体育锻炼训练中血压下降有关。
