Kumar Sanjeev, Trivedi Arvind, Verma Neetu, Panwar Ajay, Kumar Pradeep
Senior Resident, Department of Medicine, KG Medical University , Lucknow, India .
Professor, Department of Medicine, LLR Medical College , Meerut, India .
J Clin Diagn Res. 2016 May;10(5):OC44-7. doi: 10.7860/JCDR/2016/15548.7868. Epub 2016 May 1.
Diabetes mellitus is a disease with a rapidly increasing prevalence, needs continue research for novel methods to both prevent and treat this disorder. Obesity and decreased physical activity are the major risk factor for the development of diabetes. Recently the emphasis is focused on oxidative stress in pathogenesis of this disease.
To assess the serum levels of Nitric Oxide (NO) among diabetic patients and its correlation with lipid profile as well as oxidative stress in north Indian setting.
This was a cross-sectional study. Subjects suffering from type 2 diabetes for more than 1 year and age between 30 to 50 years with hyperuricaemia were included in the study. The patients were divided into three groups: Group I- Type 2 diabetics with dyslipidemia and hyperuricaemia, Group II- Type 2 diabetics with dyslipidemia and normouricaemia and Group III- Type 2 diabetics with normolipidemia and normouricaemia.
The nitric oxide level was significantly lower in Group I and Group II than Group III. The oxidative stress parameters had poor correlation with NO level in all the groups.
Our data suggests that there is definite role of Nitric Oxide (NO) in pathogenesis of type -2 diabetes mellitus with dyslipidemia and hyperuricaemia.
糖尿病是一种患病率迅速上升的疾病，需要继续研究预防和治疗这种疾病的新方法。肥胖和身体活动减少是糖尿病发生的主要危险因素。最近，人们将重点放在了这种疾病发病机制中的氧化应激上。
评估印度北部地区糖尿病患者血清一氧化氮（NO）水平及其与血脂谱以及氧化应激的相关性。
这是一项横断面研究。研究纳入了患有2型糖尿病超过1年且年龄在30至50岁之间并伴有高尿酸血症的受试者。患者被分为三组：第一组——伴有血脂异常和高尿酸血症的2型糖尿病患者，第二组——伴有血脂异常和正常尿酸血症的2型糖尿病患者，第三组——血脂正常和尿酸正常的2型糖尿病患者。
第一组和第二组的一氧化氮水平显著低于第三组。在所有组中，氧化应激参数与NO水平的相关性较差。
我们的数据表明，一氧化氮（NO）在伴有血脂异常和高尿酸血症的2型糖尿病发病机制中具有明确作用。
