Shinde Sarita N, Dhadke Vithal N, Suryakar Adinath N
Indian J Clin Biochem. 2011 Jan;26(1):74-7. doi: 10.1007/s12291-010-0041-y. Epub 2010 Dec 22.
Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications. The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls. Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels. The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II, those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications.
氧化应激增加是糖尿病及其并发症发生和发展过程中被广泛认可的一个因素。本研究旨在评估2型糖尿病患者的氧化应激情况以及补充维生素E对氧化应激的影响。本研究共纳入120名受试者，其中40名受试者为年龄和性别匹配的对照组。试验组由临床诊断的80例2型糖尿病患者组成。对对照组和糖尿病组的血清丙二醛、一氧化氮、超氧化物歧化酶、红细胞还原型谷胱甘肽和血小板聚集等生化参数进行了分析。试验组进一步分为两组：I组（n = 40），仅用降糖药物治疗的糖尿病患者；II组（n = 40），用降糖药物联合补充维生素E治疗的糖尿病患者。两组在随访3个月后再次重新评估上述所有生化参数，并将其值与其各自的基线水平进行比较。研究表明，II组（接受降糖药物联合补充维生素E治疗的患者）的氧化应激减轻，抗氧化酶活性提高，内皮功能障碍得到改善。因此，本研究可能得出结论，降糖药物联合补充维生素E可能对2型糖尿病患者有益，可将血管并发症降至最低。
