Bardak Handan, Gunay Murat, Mumcu Ugur, Bardak Yavuz
Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, Uskudar, 34668 Istanbul, Turkey.
Department of Ophthalmology, Zeynep Kamil Maternity and Children's Disease Training and Research Hospital, Uskudar, 34668 Istanbul, Turkey.
Biomed Res Int. 2016;2016:9578308. doi: 10.1155/2016/9578308. Epub 2016 Jun 29.
No study has so far evaluated the impact of coffee drinking on ocular wavefront aberration (OWA) measurements. This study presents novel findings regarding the OWA of the eye following coffee intake. We aimed to evaluate the acute changes in pupil size and OWA of the eye after single administration of coffee. A total of 30 otherwise healthy participants were included in this prospective study. All subjects drank a cup of coffee containing 57 mg caffeine. Measurements of pupil size, total coma (TC), total trefoil (TF), total spherical aberration (TSA), and total higher order aberration (HOA) were performed before and at 5 minutes, at 30 minutes, and at 4 hours after coffee drinking using a wavefront aberrometer device (Irx3, Imagine Eyes, Orsay, France). The mean age of the study population was 20.30 ± 2.74 years. Pupil size did not show a significant change during the measurements (p > 0.05). A significant increase was observed in TF and HOA measurements following coffee intake (p = 0.029 and p = 0.009, resp.). Single administration of coffee results in significant increase in TF and total HOAs in healthy subjects without any effect on pupil diameter. Ultrastructural changes in the cornea following coffee intake might be of relevance to the alterations in ocular aberrations in healthy subjects.
到目前为止，尚无研究评估喝咖啡对眼波前像差（OWA）测量的影响。本研究提出了关于摄入咖啡后眼睛OWA的新发现。我们旨在评估单次饮用咖啡后眼睛瞳孔大小和OWA的急性变化。这项前瞻性研究共纳入了30名其他方面健康的参与者。所有受试者都喝了一杯含有57毫克咖啡因的咖啡。使用波前像差仪设备（Irx3，Imagine Eyes，法国奥赛）在喝咖啡前以及喝咖啡后5分钟、30分钟和4小时测量瞳孔大小、总彗差（TC）、总三叶像差（TF）、总球差（TSA）和总高阶像差（HOA）。研究人群的平均年龄为20.30±2.74岁。测量过程中瞳孔大小未显示出显著变化（p>0.05）。摄入咖啡后，TF和HOA测量值出现显著增加（分别为p = 0.029和p = 0.009）。单次饮用咖啡会使健康受试者的TF和总HOA显著增加，而对瞳孔直径没有任何影响。摄入咖啡后角膜的超微结构变化可能与健康受试者眼像差的改变有关。
