Lyall Douglas A M, Srinivasan Sathish, Gray Lyle S
Department of Ophthalmology, University Hospital Ayr, NHS Ayrshire and Arran, Glasgow, Scotland, United Kingdom.
Optom Vis Sci. 2013 Sep;90(9):996-1003. doi: 10.1097/OPX.0b013e31829cac79.
To characterize corneal, internal, and total ocular monochromatic higher-order aberration (MHOA) changes that occur in the aging eye.
Prospective observational case series including 300 eyes of 167 patients (mean age = 63.8 years) attending the ophthalmology service at University Hospital Ayr, Scotland. Corneal, internal, and total ocular aberrations were measured over a 6-mm dilated pupil. Zernike coefficients were obtained to the sixth order. Changes in MHOA between age groups and inter-eye correlations between right and left eyes were analyzed.
A significant inter-eye correlation was found for refractive mean spherical equivalent and cylinder. A significant inter-eye correlation for the whole eye, corneal, and internal MHOA was found (p < 0.001). Right eye analysis found a significant positive correlation between age and the root mean square of whole eye MHOA (p = 0.012), with an increase from 0.517 μm in the fifth decade to 0.824 μm in the ninth. Total internal MHOA increased from 0.411 to 0.704 μm. A significant positive correlation was found between age and internal fourth- (p = 0.007), fifth- (p = 0.029), and sixth-order (p = 0.025) root mean square aberrations. There were no significant age-related changes in corneal MHOA or corneal spherical aberration. Overall mean (SD) corneal SA was 0.203 (0.082) μm.
A strong correlation between the right and left eyes exists for MHOA. Whole eye MHOA increases with age. Such changes can be attributed to age-related changes in the internal optical quality of the eye. Such normative data are useful to the cataract surgeon when considering the use of an aspherical IOL to counteract corneal-induced SA during cataract surgery.
描述衰老眼睛中角膜、眼内及全眼单色高阶像差（MHOA）的变化。
前瞻性观察病例系列，纳入了苏格兰艾尔大学医院眼科就诊的167例患者的300只眼（平均年龄 = 63.8岁）。在6mm散瞳瞳孔下测量角膜、眼内及全眼像差。获取至六阶的泽尼克系数。分析年龄组间MHOA的变化以及左右眼之间的眼间相关性。
屈光平均球镜当量和柱镜度数存在显著的眼间相关性。全眼、角膜及眼内MHOA均存在显著的眼间相关性（p < 0.001）。右眼分析发现年龄与全眼MHOA的均方根之间存在显著正相关（p = 0.012），从第五个十年的0.517μm增加到第九个十年的0.824μm。眼内总MHOA从0.411μm增加到0.704μm。年龄与眼内四阶（p = 0.007）、五阶（p = 0.029）和六阶（p = 0.025）均方根像差之间存在显著正相关。角膜MHOA或角膜球差无显著的年龄相关变化。总体平均（标准差）角膜球差为0.203（0.082）μm。
MHOA在左右眼之间存在很强的相关性。全眼MHOA随年龄增长而增加。这些变化可归因于与年龄相关的眼内光学质量变化。这些标准数据对于白内障手术医生在考虑使用非球面人工晶状体以抵消白内障手术中角膜诱导的球差时很有用。
