Chen Kang, Li Ping, Li Yi-Jun, Li Ting, Mu Yi-Ming
a Department of Endocrinology , Chinese PLA General Hospital , Beijing , China.
b Department of Endocrinology, Beijing Shijitan Hospital , Capital Medical University , Beijing , China.
Postgrad Med. 2016 Nov;128(8):783-789. doi: 10.1080/00325481.2016.1214060. Epub 2016 Aug 2.
To investigate the association between hypertriglyceridemic waist (HTGW) phenotype and arterial stiffness in a Chinese population without hypertension, diabetes and cardiovascular diseases.
A total number of 3028 subjects aged 40 years and over were enrolled in this cross-sectional study. All participants provided a clinical history and underwent a physical examination. Brachial-ankle pulse wave velocity (baPWV) was used to evaluate arterial stiffness. HTGW phenotype was defined as the simultaneous presence of waist circumference ≥90/80 cm and triglycerides ≥2.0/1.5 mmol/L in men/women.
The prevalence of HTGW phenotype was 7.5% among healthy participants in China (Beijing), 7.4% in men and 7.5% in women. Women with HTGW phenotype had a higher level of baPWV compared with normal WC and normal triglyceride (NWNT) group (P < 0.05), but no significant difference was observed in men (P > 0.05). Multiple logistic regression analysis showed HTGW phenotype was significantly associated with baPWV after controlling for multiple factors in women. However, no significant relationship was observed in men.
The present study supports that HTGW phenotype is associated with increased arterial stiffness in women but not in men.
在中国无高血压、糖尿病和心血管疾病的人群中，研究高甘油三酯腰围（HTGW）表型与动脉僵硬度之间的关联。
本横断面研究共纳入3028名40岁及以上的受试者。所有参与者均提供了临床病史并接受了体格检查。采用臂踝脉搏波速度（baPWV）评估动脉僵硬度。HTGW表型定义为男性/女性同时存在腰围≥90/80 cm且甘油三酯≥2.0/1.5 mmol/L。
中国（北京）健康参与者中HTGW表型的患病率为7.5%，男性为7.4%，女性为7.5%。与腰围正常和甘油三酯正常（NWNT）组相比，HTGW表型的女性baPWV水平更高（P<0.05），但男性未观察到显著差异（P>0.05）。多因素logistic回归分析显示，在控制多个因素后，HTGW表型与女性的baPWV显著相关。然而，在男性中未观察到显著关系。
本研究支持HTGW表型与女性动脉僵硬度增加有关，但与男性无关。
