Patel Maheshvari N, Maheshvari Jit, Patel Nayan
Clinical Research Operations, NovoBliss Research Private Limited, Ahmedabad, IND.
Pharmacology, Swaminarayan University, Ahmedabad, IND.
Cureus. 2025 Jul 31;17(7):e89118. doi: 10.7759/cureus.89118. eCollection 2025 Jul.
Background Biotin, a vital cofactor for carboxylase enzymes, plays a key role in metabolic processes, while silica is believed to support collagen synthesis, contributing to improved skin and hair health. This study investigates the dermatological benefits of standardized plant-based supplements formulated with biotin derived from and a biotin-silica blend extracted from Methods A randomized, double-blind, placebo-controlled clinical trial enrolled 105 participants, with 97 completing the 90-day study. Participants received either Treatment A (placebo), Treatment B (botanical extract of standardised for biotin, 1.25 mg orally administered), or Treatment C (botanical extract of standardised for biotin with silica, 1.25 mg biotin with 21.75 mg silica orally administered). Efficacy was evaluated through clinical and instrumental assessments of hair fall and growth rate, skin elasticity, hydration, wrinkle reduction, and nail texture. Results In the post-90-day evaluation, hair fall reduced to 20.61 ± 14.39 (p < 0.001) in biotin and 15.71 ± 10.8 (p < 0.001) in biotin with silica. Hair growth rate increased by 0.55 mm/day (p < 0.0001) in biotin and 0.57 mm/day (p < 0.0001) in biotin with silica. Nail roughness reduced to 0.09 ± 0.29 (p < 0.0001) in biotin and 0.06 ± 0.25 (p < 0.0001) in biotin with silica. Skin elasticity increased to 0.15 ± 0.06 (p < 0.0001) in biotin and 0.17 ± 0.12 (p < 0.0001) in biotin with the silica group. No adverse events were reported. Conclusion Incorporating Orgen-Bio® and RGen-Si™ into a daily routine may support overall skin, hair, and nail health. The synergistic blend enhances elasticity, reduces wrinkles, boosts hydration, strengthens hair, and improves nail quality-offering effective, long-term cosmetic and structural benefits.
背景 生物素是羧化酶的重要辅助因子，在代谢过程中起关键作用，而二氧化硅被认为有助于胶原蛋白的合成，从而改善皮肤和头发健康。本研究调查了含有源自[具体来源1]的生物素和从[具体来源2]提取的生物素 - 二氧化硅混合物的标准化植物性补充剂对皮肤的益处。方法 一项随机、双盲、安慰剂对照的临床试验招募了105名参与者，其中97人完成了为期90天的研究。参与者分别接受治疗A（安慰剂）、治疗B（标准化生物素的植物提取物，口服1.25毫克）或治疗C（标准化生物素与二氧化硅的植物提取物，口服1.25毫克生物素和21.75毫克二氧化硅）。通过对脱发和生长速度、皮肤弹性、水分含量、皱纹减少以及指甲质地的临床和仪器评估来评估疗效。结果 在90天的评估中，生物素组的脱发量降至20.61±14.39（p<0.001），生物素与二氧化硅组降至15.71±10.8（p<0.001）。生物素组的头发生长速度增加了0.55毫米/天（p<0.0001），生物素与二氧化硅组增加了0.57毫米/天（p<0.0001）。生物素组的指甲粗糙度降至0.09±0.29（p<0.0001），生物素与二氧化硅组降至0.06±0.25（p<0.0001）。生物素组的皮肤弹性增加到0.15±0.06（p<0.0001），生物素与二氧化硅组增加到0.17±0.12（p<0.0001）。未报告不良事件。结论 将Orgen - Bio®和RGen - Si™纳入日常使用可能有助于整体皮肤、头发和指甲健康。这种协同混合物可增强弹性、减少皱纹、促进保湿、强化头发并改善指甲质量，提供有效、长期的美容和结构益处。
