Center for Studies and Research on the Integument (CERT), Department of Dermatology, University Hospital of Besançon, Besançon, France ; Clinical Investigation Center, CIC-BT 506, CHRU Besançon, France.
Clin Interv Aging. 2013;8:1527-37. doi: 10.2147/CIA.S43976. Epub 2013 Nov 14.
Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many studies supporting the positive effects of topical treatment, there are no published studies demonstrating the effects of oral supplementation in the prevention of negative skin changes during winter. The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments.
This study included 80 healthy female volunteers aged 35-55 years with phototype II-IV skin. Randomization was balanced. Two tablets of a micronutrient supplement (Perfectil® Platinum) or placebo were administered once daily for 4 months. The volunteers were examined at baseline, after 4 months, and 6 weeks after termination of treatment (month 5.5). The evaluation included skin microrelief by Visioscan® as the main outcome, and the secondary outcomes were results on standard macrophotography, skin tension by Reviscometer®, skin high-frequency ultrasound, and self-assessment.
For all pseudoroughness and microrelief indicators, there was a significant increase from baseline to month 4 in the placebo group (P<0.05) but no change in the active group. Descriptive statistics for the mean minimum, mean maximum, and minimum to maximum ratio on the nonexposed study zone showed a significant and dramatic difference between baseline and month 4 and between baseline and month 5.5 (P<0.05) in the active group, indicating decreasing anisotropy of the skin. High-frequency ultrasound on the exposed study zone revealed that skin thickness was significantly decreased in the placebo group during winter but was stable in the treated group (P<0.01). The photography scaling and self-assessment questionnaire revealed no significant changes in either group.
These results indicate that the skin is prone to seasonal changes during winter, particularly in exposed areas. The data also indicate that oral supplementation can be a safe treatment, with no serious side effects, and may prevent or even eliminate the negative effects of winter on the skin.
多项研究已经证实，皮肤表面参数在冬季会发生显著变化。虽然有许多研究支持局部治疗的积极效果，但没有发表的研究表明口服补充剂在预防冬季负面皮肤变化方面的作用。本研究旨在使用非侵入性生物计量学仪器评估口服微量营养素补充剂预防冬季天气对皮肤质量产生负面影响的功效。
本研究纳入了 80 名年龄在 35-55 岁之间、皮肤类型为 II-IV 型的健康女性志愿者。随机分组平衡。两组志愿者每天服用两片微量营养素补充剂（Perfectil® Platinum）或安慰剂，持续 4 个月。在基线、4 个月后（治疗结束后 6 周，即第 5.5 个月）对志愿者进行检查。评估包括 Visioscan® 评估的皮肤微粗糙度作为主要结局，次要结局包括标准 macrophotography、Reviscometer® 评估的皮肤张力、皮肤高频超声和自我评估结果。
对于所有假性粗糙度和微粗糙度指标，安慰剂组从基线到第 4 个月均显著增加（P<0.05），而活性组无变化。非暴露研究区域的最小、最大均值和最小至最大比值的描述性统计数据显示，活性组在基线和第 4 个月以及基线和第 5.5 个月之间有显著和显著的差异（P<0.05），表明皮肤各向异性降低。暴露研究区域的高频超声显示，安慰剂组在冬季皮肤厚度显著减少，但在治疗组稳定（P<0.01）。摄影评分和自我评估问卷显示两组均无显著变化。
这些结果表明，皮肤在冬季容易发生季节性变化，特别是在暴露部位。数据还表明，口服补充剂可能是一种安全的治疗方法，没有严重的副作用，并且可以预防甚至消除冬季对皮肤的负面影响。
