Jureidini Ricardo, da Cunha José Eduardo Monteiro, Takeda Flavio, Namur Guilherme Naccache, Ribeiro Thiago Costa, Patzina Rosely, Figueira Estela Rr, Ribeiro Ulysses, Bacchella Telesforo, Cecconello Ivan
Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
Departamento de Patologia, São Paulo/SP, Brazil.
Clinics (Sao Paulo). 2016 Jul;71(6):315-9. doi: 10.6061/clinics/2016(06)05.
To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer.
Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope.
The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure.
Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.
评估微血管密度和p53表达在胰腺癌中的预后意义。
2008年至2012年期间，49例胰腺腺癌患者接受了根治性切除手术。切除的标本用抗p53和抗CD34抗体进行免疫组织化学染色。通过在高倍显微镜下对每个肿瘤切片的十个区域内的血管进行计数来评估微血管密度。
微血管密度范围为21.2至54.2个血管/mm²。20例患者（40.6%）发现p53核染色阳性。切除后的总体中位生存率为24.1个月，生存率与微血管密度或p53阳性无关。微血管密度与肿瘤直径大于3.0 cm和R0切除失败有关。
微血管密度与R1切除和较大肿瘤有关。p53表达与胰腺腺癌的肿瘤内微血管密度无关。
