Friedman B, Black J A, Hockfield S, Waxman S G, Ransom B R
Department of Neurology, Yale University School of Medicine, New Haven, Conn.
Dev Neurosci. 1989;11(2):99-111. doi: 10.1159/000111891.
Intrafascicular oligodendrocytes in myelin-deficient (md) rats typically fail to form myelin sheaths or survive to maturity. The present study of the md olfactory cortex compares astrocytes that develop either among populations of pathological oligodendrocytes in a fiber tract or that develop in neuropil, which normally contains few oligodendrocytes. Antigenic profiles for md and normal astrocytes were defined by the monoclonal antibody Rat 401, and by antibodies that recognize vimentin and glial fibrillary acidic protein. In the olfactory cortex, antigenic abnormalities were typically restricted to astrocytes located in the vicinity of pathological oligodendrocytes.
在髓磷脂缺乏（md）大鼠中，束内少突胶质细胞通常无法形成髓鞘或存活至成熟。本项对md嗅皮质的研究比较了在纤维束中病理性少突胶质细胞群体间发育的星形胶质细胞，以及在通常含极少少突胶质细胞的神经毡中发育的星形胶质细胞。通过单克隆抗体Rat 401以及识别波形蛋白和胶质纤维酸性蛋白的抗体来确定md星形胶质细胞和正常星形胶质细胞的抗原谱。在嗅皮质中，抗原异常通常局限于位于病理性少突胶质细胞附近的星形胶质细胞。
