a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
b Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center , Omaha , Nebraska , USA.
Ocul Immunol Inflamm. 2018;26(1):142-153. doi: 10.1080/09273948.2016.1195001. Epub 2016 Jul 20.
To report the imaging characteristics of acute Vogt-Koyanagi-Harada (VKH) disease using optical coherence tomography angiography (OCTA).
In this prospective study, patients with acute VKH (n = 10; mean age: 30.5 ± 13.43 years) underwent multimodal imaging (baseline and follow-up) using fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA), OCT, and OCTA. The OCTA images were analyzed to assess the retinochoroidal vasculature and compared with other imaging techniques.
During the active stage, all eyes showed multiple foci of choriocapillaris flow void that correlated with ICGA. These foci decreased in number and size after initiation of therapy. In one patient, flow void areas reappeared after cessation of therapy without any detectable change on ICGA. This patient soon developed clinical recurrence requiring re-initiation of immunosuppression.
OCTA allows high-resolution imaging of inflammatory foci suggestive of choriocapillaris hypoperfusion in acute VKH disease non-invasively. OCTA may be very helpful in the follow-up of such patients.
利用光相干断层扫描血管造影术（OCTA）报告急性 Vogt-小柳-原田病（VKH）的影像学特征。
在这项前瞻性研究中，10 例急性 VKH 患者（平均年龄：30.5±13.43 岁）接受了眼底照相、荧光素血管造影（FA）、吲哚青绿血管造影（ICGA）、OCT 和 OCTA 等多种成像方式的检查（基线和随访）。对 OCTA 图像进行分析以评估视网膜脉络膜血管，并与其他成像技术进行比较。
在活动期，所有眼睛均显示多个脉络膜毛细血管血流缺失灶，与 ICGA 相关。这些病灶在治疗开始后数量和大小减少。在一名患者中，在停止治疗后，血流缺失区域再次出现，而 ICGA 无任何可检测到的变化。该患者很快出现临床复发，需要重新开始免疫抑制治疗。
OCTA 可无创性地高分辨率成像，提示急性 VKH 病中脉络膜毛细血管灌注不足的炎症灶。OCTA 可能对这类患者的随访非常有帮助。
