Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Visual Impairment and Restoration and Key Laboratory of Myopia, Ministry of Health, Hanoi, Vietnam.
Ocul Immunol Inflamm. 2024 May;32(4):391-401. doi: 10.1080/09273948.2023.2181186. Epub 2023 Mar 1.
We explore the choroid vasculature changes of acute Vogt-Koyanagi-Harada (VKH) disease using widefield optical coherence tomography angiography (OCTA).
In this retrospective, observational, longitudinal study, 16 patients with acute VKH disease (32 eyes, mean age: 42.19 ±13.66 years) were measured using widefield OCTA.
In this study, we first described the multiple dark foci in choriocapillaris and Sattler's layer in the panoramic montage of the five 12x12mm images in 30 eyes (93.8%) of acute VKH disease. OCTA follow-up in these 30 eyes demonstrated the diminished size and number of these dark foci in choriocapillaris and Sattler's layer after the initiation of treatment.
Widefield OCTA enables noninvasive identification of characteristics of flow void at the level of superficial choroidal vessels in the acute phase and may be a novel valuable tool for diagnosis and monitoring of disease progression in VKH disease in the future.
我们使用宽视野光相干断层扫描血管造影（OCTA）来探讨急性 Vogt-小柳原田病（VKH）的脉络膜血管变化。
在这项回顾性、观察性、纵向研究中，对 16 名急性 VKH 病患者（32 只眼，平均年龄：42.19±13.66 岁）进行了宽视野 OCTA 测量。
本研究首次在 30 只眼（93.8%）的五个 12x12mm 全景图像的 panoramic montage 中描述了脉络膜毛细血管和 Sattler 层的多个暗焦点。在这些眼的 OCTA 随访中，在开始治疗后，这些脉络膜毛细血管和 Sattler 层中的暗焦点的大小和数量减少。
宽视野 OCTA 能够无创性地识别急性期浅层脉络膜血管水平的血流缺失特征，可能成为未来 VKH 病诊断和监测疾病进展的一种新的有价值的工具。
