Steg A, Leleu C, Debré B, Boccon-Gibod L, Sicard D
Department of Urology, Hôpital Cochin, Paris, France.
Eur Urol. 1989;16(3):161-4. doi: 10.1159/000471561.
Among 169 patients treated for supeficial bladder tumor with 150 mg Pasteur-strain bacillus Calmette-Guérin (BCG) intravesical instillation, 5 cases of 'BCGitis' were observed, i.e. a severe systemic BCG infection with bronchopulmonary lesions and granulomatous hepatitis. In 4 cases, the complications appeared at the early stage of treatment (after the 3rd, 6th, 6th and 8th instillations, respectively). In 1 case, treated with monthly maintenance therapy for 2 years, BCGitis appeared 6 months after treatment had been completed and, in addition to pulmonary basal infiltrate and granulomatous hepatitis, intramedullary granulomatosis was observed. In 3 patients, trauma must be taken into consideration as BCGitis appeared after traumatic instillation with bleeding. All patients were cured by treatment with rifampicin, isoniazid and prednisone.
在169例接受150毫克巴斯德菌株卡介苗（BCG）膀胱内灌注治疗浅表性膀胱肿瘤的患者中，观察到5例“卡介苗炎”，即伴有支气管肺部病变和肉芽肿性肝炎的严重全身性卡介苗感染。4例并发症出现在治疗早期（分别在第3次、第6次、第6次和第8次灌注后）。1例接受了2年的每月维持治疗，在治疗完成6个月后出现卡介苗炎，除了肺部基底浸润和肉芽肿性肝炎外，还观察到骨髓肉芽肿病。在3例患者中，由于创伤性灌注伴出血后出现卡介苗炎，必须考虑创伤因素。所有患者均通过利福平、异烟肼和泼尼松治疗治愈。
