Steg A, Leleu C, Debré B, Boccon-Gibod L, Sicard D
Dept. of Urology, Hôpital Cochin, Paris, France.
Prog Clin Biol Res. 1989;310:325-34.
Among 169 patients treated for superficial bladder tumors with intravesical instillations of 150 mg BCG-Pasteur, five developed BCG-itis--a severe systemic infection with bronchopulmonary lesions and granulomatous hepatitis. In four cases, the complication appeared early during treatment (after three, six, six and eight instillations respectively). In one case, BCG-itis appeared 6 months after completion of 2 years monthly maintenance therapy. In addition to pulmonary basal infiltration and granulomatous hepatitis, intramedullary granulomatosis was observed. In three patients, the role of trauma has to be considered, as BCG-itis appeared after a traumatic instillation with bleeding. All patients were cured by combined treatment with Rifampicin, Isoniazid and Prednisolone.
在169例接受膀胱内灌注150mg巴斯德卡介苗治疗浅表性膀胱肿瘤的患者中，有5例发生了卡介苗病——一种伴有支气管肺部病变和肉芽肿性肝炎的严重全身感染。4例患者在治疗早期出现并发症（分别在第3、6、6和8次灌注后）。1例患者在完成2年每月维持治疗6个月后出现卡介苗病。除了肺部基底浸润和肉芽肿性肝炎外，还观察到髓内肉芽肿病。3例患者必须考虑创伤的作用，因为卡介苗病是在创伤性灌注并出血后出现的。所有患者通过利福平、异烟肼和泼尼松龙联合治疗治愈。
