Kameiyama Hiroaki, Matsutomo Norikazu, Nagaki Akio, Yamao Fusae
Department of Radiological Technology, Kurashiki Central Hospital.
Nihon Hoshasen Gijutsu Gakkai Zasshi. 2016 Jul;72(7):595-601. doi: 10.6009/jjrt.2016_JSRT_72.7.595.
This study evaluates the effect of reconstruction strategies for the quantification and diagnostic accuracy of (123)I-FP-CIT SPECT.
We evaluated the quantification of (123)I-FP-CIT SPECT obtained by several combinations of reconstruction using the striatal phantom. The phantom images were reconstructed using FBP and OSEM with/without attenuation correction (AC) and scatter correction (SC). We calculated the specific binding ratio (SBR) using volume of interest (VOI) analysis on each reconstructed images. For the clinical study, 40 patients who underwent (123)I-FP-CIT SPECT were selected. We grouped the patients into the normal binding group and decreased binding group according to their clinical diagnosis. The clinical images were reconstructed under the same conditions as the phantom study. The SBRs were calculated, and a receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic accuracy.
The SBRs with AC and SC significantly increased compared with no corrections. In the clinical study, although ROC analysis showed no significant difference in the all combinations of reconstruction, the area under the curve using SC and AC tended to be higher than that obtained by other reconstruction.
Quantification of (123)I-FP-CIT SPECT was affected by reconstruction strategies. In addition, both the AC and SC improved the diagnostic accuracy of (123)I-FP-CIT SPECT. Our results suggest that both the AC and SC are recommended for the improving the quantification and diagnostic accuracy in (123)I-FP-CIT SPECT.
本研究评估重建策略对（123）I-FP-CIT单光子发射计算机断层扫描（SPECT）定量分析及诊断准确性的影响。
我们使用纹状体模型评估了通过几种重建组合获得的（123）I-FP-CIT SPECT的定量分析。模型图像采用滤波反投影（FBP）和有序子集最大期望值算法（OSEM）进行重建，重建过程中有/无衰减校正（AC）和散射校正（SC）。我们在每张重建图像上使用感兴趣区（VOI）分析计算特异性结合率（SBR）。对于临床研究，选取了40例行（123）I-FP-CIT SPECT检查的患者。根据临床诊断将患者分为正常结合组和结合降低组。临床图像在与模型研究相同的条件下进行重建。计算SBR，并进行受试者操作特征（ROC）分析以评估诊断准确性。
与未校正相比，采用AC和SC时SBR显著增加。在临床研究中，尽管ROC分析显示所有重建组合之间无显著差异，但使用SC和AC时曲线下面积往往高于其他重建方法。
（123）I-FP-CIT SPECT的定量分析受重建策略影响。此外，AC和SC均提高了（123）I-FP-CIT SPECT的诊断准确性。我们的结果表明，推荐使用AC和SC来提高（123）I-FP-CIT SPECT的定量分析及诊断准确性。
