Office of Radiation Technology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Department of Radiological, Technology, Faculty of Medical Technology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Radiol Phys Technol. 2023 Dec;16(4):569-577. doi: 10.1007/s12194-023-00746-x. Epub 2023 Oct 7.
To identify the optimal scattering correction for 123I-FP-CIT SPECT (DAT-SPECT) using a two-detector whole-body cadmium-zinc-telluride semiconductor detector (C-SPECT) system with a medium-energy high-resolution sensitivity (MEHRS) collimator. The C-SPECT system with the MEHRS collimator assessed image quality and quantification using a striated phantom. Different reconstruction methods and scattering correction settings were compared, including filtered back projection (FBP) and ordered subset expectation maximization (OSEM). Higher %contrast and %CV values were observed > 10% subwindow (SW) for all conditions, with no significant differences between images without scattering correction and those < 7% SW. The FBP images show a greater increase in %CV > 10% SW than the OSEM images. The specific binding ratio in the radioactivity ratio of 8:1 was higher than the true value under all conditions. The C-SPECT system with an MEHRS collimator provided accurate scattering suppression and enabled high-quality imaging for DAT-SPECT. Careful setting of the scattering correction is essential for total count accuracy.
使用具有中能高分辨率灵敏度 (MEHRS) 准直器的二探头全身碲锌镉半导体探测器 (C-SPECT) 系统，确定 123I-FP-CIT SPECT（DAT-SPECT）的最佳散射校正。C-SPECT 系统使用条纹体模评估图像质量和定量，使用不同的重建方法和散射校正设置进行比较，包括滤波反投影 (FBP) 和有序子集期望最大化 (OSEM)。对于所有条件，观察到 >10%子窗口 (SW) 的更高的 %contrast 和 %CV 值，无散射校正的图像与 <7% SW 的图像之间没有显著差异。FBP 图像的 %CV >10% SW 比 OSEM 图像的增加更大。在所有条件下，放射性比为 8:1 的特异性结合比均高于真实值。MEHRS 准直器的 C-SPECT 系统提供了准确的散射抑制，并实现了 DAT-SPECT 的高质量成像。散射校正的仔细设置对于总计数准确性至关重要。
