Blass Gregory, Mattson David L, Staruschenko Alexander
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F682-F685. doi: 10.1152/ajprenal.00373.2016. Epub 2016 Jul 20.
Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.
最近的证据表明，衔接蛋白SH2B3在肾脏疾病进展中起主要作用。SH2B3在造血细胞中高度表达，并调节细胞因子信号传导，诱导细胞特异性效应。此外，它在其他细胞类型中的表达表明SH2B3可能在肾脏中具有更广泛的作用。体外研究已经确定了SH2B3细胞特异性信号传导的靶点，而体内研究则观察到SH2B3对肾脏疾病进展的总体影响。这篇小型综述涵盖了表达SH2B3的细胞类型在肾脏病理中的作用及其受SH2B3的调节。
