Rossitch E, King R A, Luttinger D, Nemeroff C B
Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710.
Eur J Pharmacol. 1989 Apr 12;163(1):119-22. doi: 10.1016/0014-2999(89)90403-2.
Neurotensin and antipsychotic drugs share certain properties. This study investigates whether neurotensin and neuroleptics share the ability to produce 'anhedonia'. A dose-response curve for the effect of neurotensin on continuously reinforced behavior was obtained in Experiment 1. Centrally administered neurotensin reduced food-reinforced responding. Based on the results of Experiment 1, a dose of neurotensin (0.95 micrograms) was chosen which had minimal effects on food-reinforced operant responding. To test for anhedonia, repeated presentations of this dose were given. Because response rates did not decrease over repeated testing, no evidence for anhedonia was found.
神经降压素与抗精神病药物具有某些共同特性。本研究调查神经降压素和抗精神病药物是否具有共同产生“快感缺失”的能力。在实验1中获得了神经降压素对持续强化行为影响的剂量反应曲线。中枢给予神经降压素会降低食物强化反应。根据实验1的结果，选择了对食物强化操作性反应影响最小的神经降压素剂量（0.95微克）。为了测试快感缺失，反复给予该剂量。由于在重复测试中反应率没有下降，未发现快感缺失的证据。
