Rompré P P
Centre de recherche, Hôpital du Sacré-Coeur, Montréal, Québec, Canada.
Peptides. 1995;16(8):1417-20. doi: 10.1016/0196-9781(95)02032-2.
The curve shift method and the brain stimulation reward paradigm were used to dissociate reward and performance changes and determine whether unilateral ICV microinjection of neurotensin (3, 10, and 30 micrograms/10 microliters) produces neuroleptic- or psychostimulant-like effect on a dopamine-dependent behavior. At the highest dose tested, neurotensin potentiated brain stimulation reward, producing a significant time-dependent decrease in frequency threshold. Neurotensin also suppressed maximal rate of responding at every dose tested, suggesting that it was more effective at attenuating performance capability. These results suggest that a centrally acting neurotensin receptor agonist may specifically stimulate dopamine-dependent behaviors, producing psychostimulant-like effect that can be attenuated or masked by a suppression of performance capability.
采用曲线位移法和脑刺激奖赏范式来区分奖赏和行为表现的变化，并确定单侧脑室内微量注射神经降压素（3、10和30微克/10微升）是否会对多巴胺依赖性行为产生抗精神病药物样或精神兴奋剂样作用。在测试的最高剂量下，神经降压素增强了脑刺激奖赏，使频率阈值出现显著的时间依赖性降低。神经降压素在每个测试剂量下还抑制了最大反应速率，表明其在减弱行为表现能力方面更有效。这些结果表明，一种中枢作用的神经降压素受体激动剂可能特异性地刺激多巴胺依赖性行为，产生精神兴奋剂样作用，而这种作用可被行为表现能力的抑制所减弱或掩盖。
