The School of Kinesiology, Auburn University, Auburn, Alabama, USA.
The Department of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, Alabama, USA.
Heliyon. 2016 Apr 18;2(4):e00097. doi: 10.1016/j.heliyon.2016.e00097. eCollection 2016 Apr.
Based on its regulatory action on glucagon-like peptide 1, dipeptidyl peptidase IV (DPP-IV) has increasingly been linked to Type 2 diabetes. However, there is no evidence as to how this normal modulatory enzyme leads to pathology. It is thought that DPP-IV is affected by the development of obesity, which is a common precursor to Type 2 diabetes. Little is known about the relationship between DPP-IV activity in plasma and specific body composition measures.
In the current study, plasma DPP-IV activity and body composition measures were collected from 111 healthy subjects between the ages of 19 and 70 years old for analysis.
The mean plasma DPP-IV activity was 35.9U/L ± 12.3, falling within normal reference value range presented by Durinx et al. DPP-IV activity was negatively correlated with absolute body fat mass, but absolute lean mass was positively correlated. Consistent with the findings, DPP-IV activity was also negatively correlated with absolute gynoid fat (p = 0.0047). DPP-IV activity did not have a significant correlation with absolute android fat mass, visceral adipose tissue, BMI, and age.
From these results, it can be concluded that high activity of DPP-IV is not indicative of pathology, and specific body composition components may influence soluble DPP-IV activity in the blood.
基于对胰高血糖素样肽 1 的调节作用，二肽基肽酶 4（DPP-IV）与 2 型糖尿病的关系日益密切。然而，目前尚不清楚这种正常的调节酶如何导致病理学。人们认为 DPP-IV 受肥胖的影响，肥胖是 2 型糖尿病的常见前兆。关于血浆 DPP-IV 活性与特定身体成分测量之间的关系知之甚少。
在目前的研究中，从 111 名年龄在 19 至 70 岁的健康受试者中收集血浆 DPP-IV 活性和身体成分测量值进行分析。
平均血浆 DPP-IV 活性为 35.9U/L ± 12.3，处于 Durinx 等人提出的正常参考值范围内。DPP-IV 活性与绝对体脂肪量呈负相关，而与绝对瘦体重呈正相关。与研究结果一致，DPP-IV 活性也与绝对女性型脂肪（p=0.0047）呈负相关。DPP-IV 活性与绝对男性型脂肪量、内脏脂肪组织、BMI 和年龄无显著相关性。
从这些结果可以得出结论，DPP-IV 活性高并不表明存在病理学，特定的身体成分可能会影响血液中可溶性 DPP-IV 活性。
