Kluess Heidi A
School of Kinesiology, Auburn University, Auburn, AL, United States.
Front Physiol. 2020 Mar 3;11:148. doi: 10.3389/fphys.2020.00148. eCollection 2020.
Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body. DPP-IV has multiple targets including cytokines, neuropeptides, and incretin hormones, and plays an important role in health and disease. Recent work suggests that skeletal muscle releases DPP-IV as a myokine and participates in control of muscle blood flow. However, few of the functions of DPP-IV as a myokine have been investigated to date and there is a poor understanding about what causes DPP-IV to be released from muscle.
二肽基肽酶IV（DPP-IV）是一种独特的丝氨酸蛋白酶，在体内大多数组织中以膜结合状态和可溶性状态存在。DPP-IV有多个靶点，包括细胞因子、神经肽和肠促胰岛素激素，在健康和疾病中发挥重要作用。最近的研究表明，骨骼肌会释放DPP-IV作为一种肌动蛋白，并参与肌肉血流的控制。然而，迄今为止，作为肌动蛋白的DPP-IV的功能很少被研究，人们对导致DPP-IV从肌肉中释放的原因也知之甚少。
