Sofronov G A, Alekseev M G, Samoĭlov M O
Farmakol Toksikol. 1989 Mar-Apr;52(2):30-3.
By using the complex of techniques on the basis of life-time microscopy and spectrophotometry of the structures of II, III layers of the cat brain motor cortex there was studied the effect of ionophoretically delivered corazole on the dynamics of integral redox-state of pyramidal cells bodies, the surrounding neuropil as compared to the changed bioelectrical activity. The development of the convulsant activity of neurons coincided with the shift of their redox-state towards the accumulation of intracellular reducing equivalents. Both in the bodies of neurons and in the structures of neuropil a stable pronounced increase of restoration of intracellular redox-systems was preceded by the process of wave-like fluctuating changes in the content of reducing equivalents. The role of the revealed disturbances of oxidation-reduction processes in the mechanisms of corazole-induced lesions of neurons is discussed.
通过运用基于猫脑运动皮层II、III层结构的寿命显微镜和分光光度法的复杂技术，研究了离子电渗法给予可拉唑对锥体细胞体、周围神经纤维网整体氧化还原状态动力学的影响，并与改变的生物电活动进行了比较。神经元惊厥活性的发展与其氧化还原状态向细胞内还原当量积累的转变相吻合。在神经元胞体和神经纤维网结构中，细胞内氧化还原系统恢复的稳定显著增加之前，还原当量含量存在波浪状波动变化过程。讨论了所揭示的氧化还原过程紊乱在可拉唑诱导的神经元损伤机制中的作用。
