[Effect of kainic acid on the metabolism of intracellular calcium and oxidation-reduction processes in structures of the cerebral cortex].

The dynamics of calcium ions bound within intracellular membranes (Ca2+b), changes of redox--state and bioelectrical activity were studies in vital brain preparation after kainic acid (KA) application either to the micro--zones iontophoretically or to the whole surface of the preparation. The Ca2+b dynamics depended on KA dose and included release of Ca2+b as well as bounding of calcium attracted from extracellular space. The early period of the reaction consisted of an increased intracellular reduction equivalents and a release of Ca2+b. Theme correlating processes were followed by "seizure" activity specific for the KA effect. The calcium free bounding effect started to prevail with increasing KA dose.